Involvement of Tuberomamillary Histaminergic Neurons in Isoflurane Anesthesia
نویسندگان
چکیده
منابع مشابه
Involvement of tuberomamillary histaminergic neurons in isoflurane anesthesia.
BACKGROUND The brain histaminergic system plays a critical role in maintenance of arousal. Previous studies suggest that histaminergic neurotransmission might be a potential mediator of general anesthetic actions. However, it is not clear whether histaminergic tuberomamillary nucleus (TMN) is necessarily involved in the sedative/hypnotic effects of general anesthetics. METHODS Male Long Evans...
متن کاملExcitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone.
The histaminergic tuberomamillary nucleus (TMN) controls arousal and attention, and the firing of TMN neurons is state-dependent, active during waking, silent during sleep. Thyrotropin-releasing hormone (TRH) promotes arousal and combats sleepiness associated with narcolepsy. Single-cell reverse-transcription-PCR demonstrated variable expression of the two known TRH receptors in the majority of...
متن کاملThe effect of isoflurane anesthesia on memory
Memory and learning are considered as the most complicated and important processes of behavioral sciences. On the other hand, considering the wide .and progressively increasing applications of anesthetic agents all over the world, it is of great importance to have a reasonable knowledge regarding their effects on the memory process and its retrieval. The main purpose of this study was to evalua...
متن کاملBasal forebrain histaminergic transmission modulates electroencephalographic activity and emergence from isoflurane anesthesia.
BACKGROUND The tuberomammillary histaminergic neurons are involved in the sedative component of anesthetic action. The nucleus basalis magnocellularis (NBM) in the basal forebrain receives dense excitatory innervation from the tuberomammillary nucleus and is recognized as an important site of sleep-wake regulation. This study investigated whether NBM administration of histaminergic drugs may mo...
متن کاملComparison of the Use of Mask or Chamber in Inducing Anesthesia with Isoflurane in Rabbits
Objective- To study the effects of Isoflurane in inducing anesthesia and comparing mask and chamber induction anesthesia in rabbits for the first trial in Iran. Design- Experimental design. Animals- 20 female adult New Zealand White rabbits. Procedures- Animals were divided randomly into two groups. A 40 cm3 Chamber was used in group A with 4-5% concentration of isoflurane and a face mask ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Anesthesiology
سال: 2011
ISSN: 0003-3022
DOI: 10.1097/aln.0b013e3182207655